FCN-437c | CDK4/6 inhibitor | Probechem Biochemicals

Chemical Structure : FCN-437c

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FCN-437c (FCN-437)

货号: PC-24695Not For Human Use, Lab Use Only.

FCN-437c (FCN-437) is a potent, selective and orally active inhibitor of CDK4/6, shows selective inhibitory activities against CDK4/6 over other CDKs.

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生物&药学活性

FCN-437c (FCN-437) is a potent, selective and orally active inhibitor of CDK4/6, shows selective inhibitory activities against CDK4/6 over other CDKs.
FCN-437 is 5-fold more potent than ribociclib, and comparable to palbociclib.
FCN-437 dramatically inhibited tumor growth, comparable or superior to approved CDK4/6 inhibitors.
FCN-437 possesses good synergetic effect in combination with letrozole or fulvestrant in vivo.

物理化学性质&存储条件

分子量	548.75
分子式	C29H40N8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-cyclopentyl-N,N-dimethyl-2-((5-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)thieno[3,2-d]pyrimidine-6-carboxamide

参考文献

1. Shu Lin, et al. Cancer Res (2019) 79 (13_Supplement): 4425.

FCN-437c (FCN-437)

生物&药学活性

物理化学性质&存储条件

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FCN-437c (FCN-437)

生物&药学活性

物理化学性质&存储条件

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