FAK PROTAC FC-11

Chemical Structure : FAK PROTAC FC-11

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货号: PC-25160Not For Human Use, Lab Use Only.

FAK PROTAC FC-11 is a potent and highly selective FAK PROTAC degrader with DC50 of 0.08 nM in PA-1 cells.

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生物&药学活性

FAK PROTAC FC-11 is a potent and highly selective FAK PROTAC degrader with DC50 of 0.08 nM in PA-1 cells.
FC-11 is based on a CRBN-mediated and proteasome-dependent mechanism.
FC-11 has DC50 as 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells.
FC-11 exhibits rapid and highly efficient degradation of FAK in various cell lines with a DC50 at picomolar potencies for 8 h treatment.

物理化学性质&存储条件

分子量	949.92
分子式	C41H42F3N13O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-1,2,3-Triazole-4-carboxamide, 1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-

参考文献

1. Gao H, et al. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862.

FAK PROTAC FC-11

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物理化学性质&存储条件

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FAK PROTAC FC-11

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