FAH65

Chemical Structure : FAH65

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货号: PC-24656Not For Human Use, Lab Use Only.

FAH65 is a potent, APP-selective BACE1 inhibitor with IC50 of 0.01 uM in in cell-free assays.

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生物&药学活性

FAH65 is a potent, APP-selective BACE1 inhibitor with IC50 of 0.01 uM in in cell-free assays.
FAH65 displays selectivity for inhibition of APP cleavage with little activity against other BACE1 substrates neuregulin 1 (NRG1) or p-selectin glycoprotein ligand-1 (PSGL1).
FAH65 inhibits sAPPβ and Aβ1-42 production in APP-expressing cells in vitro.
FAH65 reduces BACE1 cleavage products soluble APPβ (sAPPβ) and the β C-terminal fragment (βCTF), as well as amyloid-β (Aβ) 1-40 and 1-42 in vivo in an animal model of AD.
FAH65 improved the discrimination score in the Novel Object Recognition (NOR) memory testing paradigm in murine model of AD.

物理化学性质&存储条件

分子量	423.42
分子式	C22H19F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-5-(4-(difluoromethoxy)-3-methylphenyl)-3-methyl-5-(3-(pyrimidin-5-yl)phenyl)-3,5-dihydro-4H-imidazol-4-one

参考文献

1. Campagna J, et al. Neurotherapeutics. 2025 May 20:e00610.

FAH65

生物&药学活性

物理化学性质&存储条件

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FAH65

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物理化学性质&存储条件

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