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首页-小分子抑制剂&激动剂-Others-Other Targets-F35-303
F35-303

Chemical Structure : F35-303

CAS No.: 1585408-68-9

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F35-303

货号: PC-28412Not For Human Use, Lab Use Only.

F35-303 is a small molecule inhibitor of BEX4-XRCC5 interaction with IC50 of 2.39 uM in Huh6 cells, exhibits binding affinity for XRCC5 with SPR KD of 0.751 uM, suppresses NHEJ repair activity and reduces HB cells cell viability, inhibits cisplatin resistance.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

F35-303 is a small molecule inhibitor of BEX4-XRCC5 interaction with IC50 of 2.39 uM in Huh6 cells, exhibits binding affinity for XRCC5 with SPR KD of 0.751 uM, suppresses NHEJ repair activity and reduces HB cells cell viability, inhibits cisplatin resistance.

物理化学性质&存储条件

分子量 303.34
分子式 C16H18FN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[(3S)-3-amino-1-pyrrolidinyl]-3-[5-(4-fluorophenyl)-2-oxazolyl]-1-propanone

参考文献

1. Yan Z, et al. Pharmacol Res. 2026 Sep 30;233:109658.

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