F1929-1458

Chemical Structure : F1929-1458

CAS No.: 55480-45-0

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货号: PC-24780Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

F1929-1458 is a small molecule NFKB1 (Nuclear factor κB subunit 1, NF-κB subunit 1) agonist, activates NF-κB signaling pathway, promotes anti-tumor immunity by remodeling the TME and activating DCs.
F1929-1458 elicits cellular stress, causing tumor cells to release DAMPs (HMGB1-gDNA complex, ATP, and OxLDL)..
F1929-1458 stimulate the cGAS-STING and NLRP3 inflammasome pathways in DCs, resulting in the generation of type I IFNs and IL-1β.
F1929-1458 treatment enhanced T cell infiltration and T cell mediated tumor regression.
F1929-1458 and the anti-PD-1 antibody exhibited a synergistic anti-tumor effect.

物理化学性质&存储条件

分子量	172.23
分子式	C8H16N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-methylpiperazin-1-yl)propanoic acid

参考文献

1. Ying Chen, et al. J Transl Med. 2025 May 20;23(1):561.

F1929-1458

生物&药学活性

物理化学性质&存储条件

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F1929-1458

生物&药学活性

物理化学性质&存储条件

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