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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-Ethylisopropylamiloride
Ethylisopropylamiloride

Chemical Structure : Ethylisopropylamiloride

CAS No.: 1154-25-2

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Ethylisopropylamiloride (EIPA, L593754, MH 12-43)

货号: PC-28233Not For Human Use, Lab Use Only.

Ethylisopropylamiloride (EIPA) is specific macropinocytosis inhibitor that inhibits endocytosis via the macropinocytic pathway, also inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 10.5 uM, inhibits epithelial sodium channels (ENaC) as well as of several other Na+/H+ antiporters.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ethylisopropylamiloride (EIPA) is specific macropinocytosis inhibitor that inhibits endocytosis via the macropinocytic pathway, also inhibits TRPP3-mediated Ca2+-activated currents with IC50 of 10.5 uM, inhibits epithelial sodium channels (ENaC) as well as of several other Na+/H+ antiporters.

物理化学性质&存储条件

分子量 299.76
分子式 C11H18ClN7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Amino-N-carbamimidoyl-6-chloro-5-(ethyl(isopropyl)amino)pyrazine-2-carboxamide

参考文献

1. Nakase I, et al. Mol Ther. 2004 Dec;10(6):1011-22.

2. Dai XQ, et al. Mol Pharmacol. 2007 Dec;72(6):1576-85.

3. Mercer J, et al. Nat Cell Biol. 2009;11:510–520.

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