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Equilin

Chemical Structure : Equilin

CAS No.: 474-86-2

Equilin (7-Dehydroestrone)

货号: PC-21635Not For Human Use, Lab Use Only.

Equilin (7-Dehydroestrone) is a highly potent 3βHSD1 inhibitor with IC50 of 2.8 nM in VCaP cells, also inhibits the activity of purified 3βHSD1 with SPR KD of 2.23 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Equilin (7-Dehydroestrone) is a highly potent 3βHSD1 inhibitor with IC50 of 2.8 nM in VCaP cells, also inhibits the activity of purified 3βHSD1 with SPR KD of 2.23 uM.
Equilin has a higher affinity to 3βHSD1 than BCA.
Equilin suppresses UBE3D-related tumor aggressiveness.

物理化学性质&存储条件

分子量 268.36
分子式 C18H20O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(9S,13S,14S)-3-Hydroxy-13-methyl-6,9,11,12,13,14,15,16-octahydro-17H-cyclopenta[a]phenanthren-17-one

参考文献

1. Xuebin Zhang, et al. J Clin Invest. 2023 Dec 15;133(24):e171199.

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