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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Thyroid Hormone Receptor (THR)-Eprotirome
Eprotirome

Chemical Structure : Eprotirome

CAS No.: 355129-15-6

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Eprotirome (KB-2115, KB2115)

货号: PC-24487Not For Human Use, Lab Use Only.

Eprotirome (KB-2115) is a liver-specific thyromimetic and thyroid hormone receptor-beta (TRβ) agonist with modestly higher affinity for TRβ than for TRα, reduces serum cholesterol independent of the LDL receptor.

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50 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Eprotirome (KB-2115) is a liver-specific thyromimetic and thyroid hormone receptor-beta (TRβ) agonist with modestly higher affinity for TRβ than for TRα, reduces serum cholesterol independent of the LDL receptor.
Eprotirome (KB-2115) is a potent and effective reducer of serum LDL cholesterol in LDLR−/− mice.
Eprotirome (KB-2115) also prevented hepatic steatosis but did not induce fasting hyperglycemia, increase basal EGP rate, or diminish hepatic insulin sensitivity in in fat-fed rats.

物理化学性质&存储条件

分子量 487.14
分子式 C18H17Br2NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl)amino)-3-oxopropanoic acid

参考文献

1. Lin JZ, et al. Endocrinology. 2012 Dec;153(12):6136-44.

2. Ladenson PW, et al. N Engl J Med. 2010 Mar 11;362(10):906-16.

3. Vatner DF, et al. Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E89-100.

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