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首页-抗体和重组蛋白-Biosimilar Antibody-Enfortumab
Enfortumab

Chemical Structure : Enfortumab

CAS No.:

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Enfortumab (Anti-human Nectin-4 mAb, human IgG1-Kappa)

货号: PC-Ab1114Not For Human Use, Lab Use Only.

Nectin-4 is a tumour-associated antigen found on the surface of most urothelial carcinoma cells. In the antibody-drug conjugate enfortumab vedotin, human anti-nectin-4 antibody is linked to the cytotoxic microtubule-disrupting agent monomethyl auristatin E. Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for ADC in the very limited armamentarium against TNBC..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nectin-4 is a tumour-associated antigen found on the surface of most urothelial carcinoma cells. In the antibody-drug conjugate enfortumab vedotin, human anti-nectin-4 antibody is linked to the cytotoxic microtubule-disrupting agent monomethyl auristatin E. Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for ADC in the very limited armamentarium against TNBC.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Enfortumab; Enfortumab vedotin; Anti-human Nectin-4; Anti-human cell adhesion molecule nectin-4

参考文献

1. 1, Challita-Eid PM, et al. Cancer Res. 2016 May 15;76(10):3003-13. 2, Takahashi S, et al. Invest New Drugs. 2020 Aug;38(4):1056-1066. 3, Chang E, et al. Clin Cancer Res. 2021 Feb 15;27(4):922-927. 4, Powles T, et al. N Engl J Med. 2021 Mar 25;384(12):1125-1135. 5, Yu EY, et al. Lancet Oncol. 2021 Jun;22(6):872-882.

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