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首页-小分子抑制剂&激动剂-Others-Other Targets-Eloralintide sodium
Eloralintide sodium

Chemical Structure : Eloralintide sodium

CAS No.:

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Eloralintide sodium (LY-3841136 sodium)

货号: PC-24950Not For Human Use, Lab Use Only.

Eloralintide sodium (LY3841136) is a selective amylin mimetic and long acting amylin receptor (AMYR) agonist, binds to amylin receptors with high selectivity from calcitonin receptors.

规格 价格 库存 数量
2 mg ￥2480 In stock
5 mg ￥3980 In stock
10 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Eloralintide sodium (LY3841136) is a selective amylin mimetic and long acting amylin receptor (AMYR) agonist, binds to amylin receptors with high selectivity from calcitonin receptors.
Eloralintide (LY3841136) demonstrates prolonged plasma half-life and reduced clearance compared to cagrilintide.
Eloralintide (LY3841136) matched the food intake reductions of cagrilintide, resulting in a similar degree on body weight change, without the same degree of conditioned taste avoidance, in rats。
Eloralintide (LY3841136) lowered body weight primarily by loss of fat mass and with more potent effects for weight loss efficacy, food intake lowering, and fat mass reductions in DIO rats.

物理化学性质&存储条件

分子量 4526.10 (free base)
分子式 C201H319N49O65S2.xNa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Sequence: {γGlu}-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gly-{Orn}-Leu-Ala-Glu-{(α-Me-Phe)}-Leu-Val-Arg-Ser-Ser-Asn-{(N-Me-Asn)}-Phe-Gly-Pro-{Lys(γGlu-γGlu-C20 diacid)}-Leu-Pro-Pro-Thr-Glu-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Methylene bridge: Cys2-Cys7)

参考文献

1. DANIEL A. BRIERE, et al. Diabetes 2025;74(Supplement_1):849-P.

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