Ellorarxine | RAR modulator | Probechem Biochemicals

Chemical Structure : Ellorarxine

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Ellorarxine (DC645, NVG0645)

货号: PC-24566Not For Human Use, Lab Use Only.

Ellorarxine (DC645, NVG0645) is a synthetic retinoic acid and mimic of all-trans-retinoic acid, and a potent, CNS-permeable RAR modulator.

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生物&药学活性

Ellorarxine (DC645, NVG0645) is a synthetic retinoic acid and mimic of all-trans-retinoic acid, and a potent, CNS-permeable RAR modulator.
Ellorarxine upregulates expression of Cyp26b1 and RARβ.
Ellorarxine caused RARα in C6 cells to migrate towards one pole of the nucleus and RARγ in differentiated SH-SY5Y neurons to migrate towards the cell membrane.
Ellorarxine pretreatment alleviates mitochondrial dysfunction in SH-SY5Y cells, reduces cell death.
Ellorarxine selectively modulated microglia inflammatory cytokine release, also displays both antioxidant and anti-inflammatory effects.
Ellorarxine displays a wide-range of positive effects in a commonly used in vitro SOD1G93A NSC-34 mouse cell model of ALS

物理化学性质&存储条件

分子量	334.42
分子式	C21H22N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)ethynyl]benzoic acid

参考文献

1. Escudier O, et al. Int J Mol Sci. 2024 Sep 10;25(18):9764.

2. Zhang Y, et al. Int J Mol Sci. 2025 Apr 10;26(8):3551.

Ellorarxine (DC645, NVG0645)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ellorarxine (DC645, NVG0645)

生物&药学活性

物理化学性质&存储条件

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