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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-Eleclazine
Eleclazine

Chemical Structure : Eleclazine

CAS No.: 1443211-72-0

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Eleclazine (GS-6615, GS6615)

货号: PC-26048Not For Human Use, Lab Use Only.

Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).
Eleclazine (GS6615) is 42 times more potent than Ranolazine in reducing ischemic burden in vivo (EC50=190 nM).

物理化学性质&存储条件

分子量 415.37
分子式 C21H16F3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(Pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

参考文献

1. Zablocki JA, et al. J. Med. Chem., 2016, 59 (19), pp 9005–9017

2. Fuller H, et al. Heart Rhythm. 2016 Aug;13(8):1679-86.

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