Edecesertib (GS-5718) | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : Edecesertib

CAS No.: 2408839-73-4

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货号: PC-22269Not For Human Use, Lab Use Only.

Edecesertib (GS-5718) is a potent, selective, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 0.6 nM.

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Edecesertib (GS-5718) is a potent, selective, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 0.6 nM.

Edecesertib (GS-5718) displays good potency in a human whole blood cellular assay (EC50 = 124 nM).

Edecesertib (GS-5718) is 123-fold less potent for IRAK1 and >500-fold selectivity over a panel of kinases.

Edecesertib (GS-5718) demonstrated efficacy in a mouse NZB lupus model.

分子量	435.46
分子式	C22H22FN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[(1R)-1-Cyanoethyl]amino]-6-(3-cyanopyrrolo[1,2-b]pyridazin-7-yl)-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-3-pyridinecarboxamide

1. Patent WO2020014468 A1.
2, Ammann SE, et al. J Med Chem. 2025 May 15. doi: 10.1021/acs.jmedchem.5c00463.