Ebio2

Chemical Structure : Ebio2

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货号: PC-23868Not For Human Use, Lab Use Only.

Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV.

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生物&药学活性

Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV.
Ebio2 (10 nM) enhances KCNQ2 currents by an average factor of 7.4 ± 0.3 and considerably shifted the half-maximal activation voltage (V1/2) to a more hyperpolarized potential by 32.7 ± 1.2 mV, from −15.2 ± 1.6 mV to −47.8 ± 1.6 mV.
Ebio2 also shifts the KCNQ2 activation curve to a hyperpolarizing direction, with an EC50 value of 4.5 nM.
Ebio2 exhibits over 100 times greater potency in modulating the KCNQ2 channel than Ebio1 (Cat# PC-21613).
Ebio2 exhibits over 100-fold subtype selectivity compared to all other KCNQ channels.

物理化学性质&存储条件

分子量	335.35
分子式	C17H19F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(7-(difluoromethoxy)-1-(prop-2-yn-1-yl)-1H-indazol-3-yl)-3,3-dimethylbutanamide

参考文献

1. Li J, et al. Nat Chem Biol. 2025 Jan 15. doi: 10.1038/s41589-024-01834-8.

Ebio2

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Ebio2

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