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EYA2 degrader EC21

Chemical Structure : EYA2 degrader EC21

CAS No.:

EYA2 degrader EC21

货号: PC-27139Not For Human Use, Lab Use Only.

EYA2 degrader EC21 is a bifunctional small molecule EYA2 degrader via CDK6 recruitment, enhances the interaction between CDK6 and EYA2, thereby promoting EYA2 degradation, disrupts DNA damage repair pathways and significantly suppresses breast cancer cell proliferation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EYA2 degrader EC21 is a bifunctional small molecule EYA2 degrader via CDK6 recruitment, enhances the interaction between CDK6 and EYA2, thereby promoting EYA2 degradation, disrupts DNA damage repair pathways and significantly suppresses breast cancer cell proliferation.

物理化学性质&存储条件

分子量 1013.12
分子式 C53H60N10O11
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-N-(14-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-14-oxo-3,6,9,12-tetraoxatetradecyl)-5-((2-(3-phenoxybenzoyl)hydrazineylidene)methyl)furan-2-carboxamide

参考文献

1. Zhang Y, et al. Eur J Med Chem. 2026 Jun 18;317:119065.

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