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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-ATP Citrate Lyase (ACL, ACLY) -EVT0185
EVT0185

Chemical Structure : EVT0185

CAS No.: 2588489-03-4

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EVT0185 (EVT-0185)

货号: PC-25220Not For Human Use, Lab Use Only.

EVT0185 (EVT-0185) is a novel, orally available small molecule inhibitor of ATP citrate lyase (ACLY), inhibits de novo lipogenesis with IC50 of 0.46 uM in mouse primary hepatocytes.

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5 mg ￥3580 In stock
10 mg ￥5580 In stock
25 mg ￥8580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EVT0185 (EVT-0185) is a novel, orally available small molecule inhibitor of ATP citrate lyase (ACLY), inhibits de novo lipogenesis with IC50 of 0.46 uM in mouse primary hepatocytes.
EVT0185 is activated in hepatocytes via SLC27A2-dependent conversion to its CoA-thioester form (EVT0185-CoA), allowing liver-specific action while sparing non-hepatic tissues.
EVT0185-CoA directly interacts with the CoA-binding site of ACLY.
EVT0185 more potently inhibits fatty acid and cholesterol synthesis from lactate and acetate than bempedoic acid (Cat#PC-43001) in WT hepatocytes.
EVT0185-CoA inhibits rather than activated AMPKβ1-containing complexes, and also inhibits ACC1, ACC2 and ACSS2.
EVT0185 also suppresses clonogenic survival of human (Hep3B) and mouse (Hepa1-6) HCC cell lines more effectively than bempedoic acid.
EVT0185 (100 mg/kg) reduces tumour burden in distinct mouse models of MASH-HCC, promotes tumour-infiltrating B cells.

物理化学性质&存储条件

分子量 362.51
分子式 C22H34O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[4-(5-carboxy-5-methyl-hexyl)-phenyl]−2,2-dimethylhexanoic acid

参考文献

1. Gautam J, et al. ACLY inhibition promotes tumour immunity and suppresses liver cancer. Nature. 2025 Jul 30. doi: 10.1038/s41586-025-09297-0.

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