ERD-308 | ER PROTAC | Probechem Biochemicals

Chemical Structure : ERD-308

CAS No.: 2320561-35-9

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ERD-308 (ERD308)

货号: PC-73165Not For Human Use, Lab Use Only.

ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively.

规格	价格	库存
5 mg	￥2380	In stock
10 mg	￥3880	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively.
ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in MCF-7 and T47D ER+ breast cancer cell lines.
ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells.

物理化学性质&存储条件

分子量	1004.26
分子式	C55H65N5O9S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(2-((5-(Ethyl(2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)phenoxy)ethyl)amino)pentyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Jiantao Hu, et al. J Med Chem. 2019 Feb 14;62(3):1420-1442.

ERD-308 (ERD308)

生物&药学活性

物理化学性质&存储条件

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ERD-308 (ERD308)

生物&药学活性

物理化学性质&存储条件

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