ERAP1 inhibitor N1 | ERAP1 inhibitor | Probechem Biochemicals

Chemical Structure : ERAP1 inhibitor N1

CAS No.: 479-43-6

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ERAP1 inhibitor N1 (Canthin-6-one)

货号: PC-25723Not For Human Use, Lab Use Only.

ERAP1 inhibitor N1 is a selective small molecule ERAP1 inhibitor, disrupts its function in Hedgehog (HH) signaling pathway (IC50=46.24 nM).

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1 mg	￥1480	In stock
5 mg	￥3480	In stock
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25 mg		Get quote

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生物&药学活性

ERAP1 inhibitor N1 is a selective small molecule ERAP1 inhibitor, disrupts its function in Hedgehog (HH) signaling pathway (IC50=46.24 nM).
ERAP1 inhibitor N1 inhibits the ERAP1/USP47 interaction by increasing the stability of βTrCP.
ERAP1 inhibitor N1 inhibits HH-dependent cell growth of cerebellar granule neuron progenitors.
ERAP1 inhibitor N1 suppresses the growth of primary HH-MB cells in vitro.
ERAP1 inhibitor N1 can crosse the BBB and inhibits the growth of primary HH-MB in an orthotopic implantation model.

物理化学性质&存储条件

分子量	220.23
分子式	C14H8N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

参考文献

1. Bufalieri F, et al. Mol Ther. 2025 Oct 17:S1525-0016(25)00857-3.

ERAP1 inhibitor N1 (Canthin-6-one)

生物&药学活性

物理化学性质&存储条件

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ERAP1 inhibitor N1 (Canthin-6-one)

生物&药学活性

物理化学性质&存储条件

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