ERAP1 inhibitor 3 (ERAP1-IN-1)

Chemical Structure : ERAP1 inhibitor 3

CAS No.: 865273-97-8

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货号: PC-72272Not For Human Use, Lab Use Only.

ERAP1 inhibitor 3 (ERAP1-IN-1) is a selective, small molecule inhibitor of ERAP1 with IC50 of 0.4 uM, displays no inhibitory effect against its paralogues ERAP2 and IRAP.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2880	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ERAP1 inhibitor 3 (ERAP1-IN-1) is a selective, small molecule inhibitor of ERAP1 with IC50 of 0.4 uM, displays no inhibitory effect against its paralogues ERAP2 and IRAP.
ERAP1 inhibitor 3 allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates.
ERAP1 inhibitor 3 inhibited antigen presentation in a cellular assay.
Compound 3 displays higher potency for an ERAP1 variant associated with increased risk of autoimmune disease.

物理化学性质&存储条件

分子量	458.452
分子式	C20H21F3N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Methoxy-3-(N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid

参考文献

1. Zachary Maben, et al. J Med Chem. 2020 Jan 9;63(1):103-121.