ER-464195-01 | Calreticulin-Integrin α inhibitor | Probechem Biochemicals

Chemical Structure : ER-464195-01

CAS No.: 859218-37-4

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ER-464195-01 (ER464195-01)

货号: PC-35072Not For Human Use, Lab Use Only.

ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5.

规格	价格	库存
2 mg	￥2980	In stock
5 mg	￥4880	In stock
10 mg	￥7580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5.
ER-464195-01 dose-dependently and specificly inhibits GST-fused CRT proteins binding to ITGA4 in vitro pull-down assay.
ER-464195-01 inhibits the PMA-induced T cells and the fMLP-stimulated neutrophils bound to VCAM1 (IC50=0.15 μM) and ICAM-1 (IC50=0.19 μM), respectively.
ER-464195-01 suppresses the cell adhesion and the migration of leukocytes, prevents colitis and downregulates the expression of inflammation-related genes in DSS-treated mice, ameliorates the severity of disease in IBD mouse models.

物理化学性质&存储条件

分子量	379.029
分子式	C23H39ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-propyl-4-(2-(3,3,5,5-tetramethylcyclohexyl)phenyl)piperazine hydrochloride

参考文献

1. Ohkuro M, et al. Nat Commun. 2018 May 17;9(1):1982.

ER-464195-01 (ER464195-01)

生物&药学活性

物理化学性质&存储条件

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ER-464195-01 (ER464195-01)

生物&药学活性

物理化学性质&存储条件

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