EPM35 | Bacterial efflux pump modulator | Probechem Biochemicals

Chemical Structure : EPM35

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EPM35 (Efflux pump modulator 35)

货号: PC-21349Not For Human Use, Lab Use Only.

EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load.

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生物&药学活性

EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load.
EPM35 disrupts the growth of a Gram-negative human pathogen, Salmonella enterica serotype Typhimurium (S. Typhimurium), in macrophages.
EPM35 shows little effect on bacterial growth in standard microbiological media.
EPM35 prevents energy-dependent efflux pump activity in Salmonella and bound the AcrB subunit of the AcrAB-TolC efflux system with KDs in the micromolar range.
EPM35 could disrupt infection by specifically interfering with the export of bacterial toxic metabolites, host defense factors, and/or antibiotics.
EPM35 display antibacterial synergy with antimicrobial peptides, a class of host innate immune defense molecules present in body fluids and cells.
EPM35 also has synergistic activity with antibiotics exported by AcrAB-TolC in broth and in macrophages and inhibits efflux pump activity in MDR Gram-negative ESKAPE clinical isolates.

物理化学性质&存储条件

分子量	465.30
分子式	C19H21Cl2F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dichlorophenoxy)-3-(4-((4-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)propan-2-ol

参考文献

1. Abigail L Reens, et al. PLoS Pathog. 2018 Jun 7;14(6):e1007115.

2. Samual C Allgood, et al. mBio. 2023 Nov 3:e0249223.

EPM35 (Efflux pump modulator 35)

生物&药学活性

物理化学性质&存储条件

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EPM35 (Efflux pump modulator 35)

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物理化学性质&存储条件

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