欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-EPIC-1042
EPIC-1042

Chemical Structure : EPIC-1042

CAS No.:

加入收藏

EPIC-1042 (EPIC1042)

货号: PC-25656Not For Human Use, Lab Use Only.

EPIC-1042 is a potent, small molecule PTRF/Cavin1-caveolin-1 interaction inhibitor with IC50 of 38 uM, inhibits the binding of PTRF to Caveolin-1 (CAV1), resulting in decreased secretion of small extracellular vesicles (sEVs).

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EPIC-1042 is a potent, small molecule PTRF/Cavin1-caveolin-1 interaction inhibitor with IC50 of 38 uM, inhibits the binding of PTRF to Caveolin-1 (CAV1), resulting in decreased secretion of small extracellular vesicles (sEVs).
EPIC-1042 prevents temozolomide efflux by inhibiting small extracellular vesicles secretion, inhibits autophagy flux in the later stage.
EPIC-1042 could specifically inhibit the secretion of sEVs by disrupting the interaction between PTRF and CAV1.
EPIC-1042 inhibits autophagy flux and increase TMZ sensitivity in vivo.
EPIC-1042 could enhance TMZ efficacy in MGMT-deficient GBM tumors in vivo.
EPIC-1042 induces p62-mediated autophagic PARP1 degradation.
EPIC-1042 enhances TMZ sensitivity in MGMT-positive GBM cells.
EPIC-1042 enhances TMZ sensitivity in dose-dependent and long-term treatment manners in MGMT-deficient tumors in vivo.

物理化学性质&存储条件

分子量 350.47
分子式 C20H26N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2-aminoethyl)amino)-1-(benzylamino)-7-ethyl-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile

参考文献

1. Hong B, et al. Neuro Oncol. 2024 Jan 5;26(1):100-114.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: