EPIC-0726 | PTRF PROTAC | Probechem Biochemicals

Chemical Structure : EPIC-0726

加入收藏

EPIC-0726 (EPIC0726)

货号: PC-25655Not For Human Use, Lab Use Only.

EPIC-0726 is a selective PROTAC degrader of polymerase I and transcript release factor (PTRF/Cavin1) with DC50 of 5.12 uM in U87-MG cells, Dmax=90.07%.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

EPIC-0726 is a selective PROTAC degrader of polymerase I and transcript release factor (PTRF/Cavin1) with DC50 of 5.12 uM in U87-MG cells, Dmax=90.07%.
EPIC-0726 induces PTRF degradation in pancreatic (PANC-1), hepatocellular (HepG2), lung (A459), and breast (MDA-MB-231) cancer cell lines with DC50 of 10.95 μM, 3.59 μM, 6.00 μM, and 6.60 μM, respectively.
Pharmacological UPS inhibition via MG132 abolished EPIC-0726-mediated degradation.
EPIC-0726 exhibits anti-proliferative efficacy in N37 and HYF cells with IC50 of 18.84 and 16.24 μM, respectively.
EPIC-0726 reduced CAV1 protein levels in a concentration-dependent manner, aligning with the established mechanism whereby PTRF downregulation induces CAV1 degradation.
EPIC-0726 (30 mg/kg, oral) inhibited GBM growth and synergized with TMZ.

物理化学性质&存储条件

分子量	733.92
分子式	C41H51N9O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10-(6-((2-aminoethyl)amino)-8-(benzylamino)-5-cyano-3,4-dihydro-2,7-naphthyridin-2(1H)-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)decanamide

参考文献

1. Biao Hong, et al. Neuro Oncol. 2025 Oct 27:noaf253.

EPIC-0726 (EPIC0726)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

EPIC-0726 (EPIC0726)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.