EP4 agonist 11a

Chemical Structure : EP4 agonist 11a

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货号: PC-27998Not For Human Use, Lab Use Only.

EP4 agonist 11a is a potent, selective and non-prostanoid agonist of prostaglandin E2 receptor EP4 with EC50 of 2.1 nM (hEP4).

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生物&药学活性

EP4 agonist 11a is a potent, selective and non-prostanoid agonist of prostaglandin E2 receptor EP4 with EC50 of 2.1 nM (hEP4).
EP4 agonist 11a binds orthosterically to the PGE2 site in the EP4 receptor despite structural differentiation from prostanoids.
EP4 agonist 11a induces hemodynamic changes in mouse, a known on-target effect of EP4 agonists in systemic circulation.

物理化学性质&存储条件

分子量	465.48
分子式	C22H26F3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((R)-3-methyl-4-(4-(((S)-1-phenylethyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-4-oxobutanoic acid

参考文献

1. Perez HL, et al. J Med Chem. 2026 Apr 23;69(8):9406-9440.

EP4 agonist 11a

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EP4 agonist 11a

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