ENDO12 (ENDOtollin12)

Chemical Structure : ENDO12

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货号: PC-26478Not For Human Use, Lab Use Only.

ENDO12 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG, directly binds to recombinant STX7 with SPR KD of 2.7 uM.

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250 mg		Get quote

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生物&药学活性

ENDO12 is a specific small-molecule inhibitor of syntaxin 7 (STX7)-Munc13-4 interaction, selectively blocks endosomal TLRs (eTLRs) endosomal signaling, inhibits CD40 mobilization in Cal1 cells stimulated with CpG, directly binds to recombinant STX7 with SPR KD of 2.7 uM.
ENDO12 specifically inhibits activation through CpG but does not inhibit exocytosis through plasma membrane ligands.
ENDO12 inhibits STX7–MUNC-13-4 binding but is negative in TR-FRET counterscreens using MUNC13-4 and Rab11 or Rab27a.
ENDO12 does not affect the binding of STX7 to the SNARE protein VAMP8.
ENDO12 reduces inflammation but spares antiviral response, significantly inhibits IL-6 production following CpG or CL097 stimulation in mouse primary splenic CD11c+ DCs.

物理化学性质&存储条件

分子量	288.33
分子式	C15H17FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-5-(diethylamino)-2-((5-fluoropyridin-2-yl)diazenyl)phenol

参考文献

1. Jennifer L Johnson, et al. Nat Chem Biol. 2026 Apr 6. doi: 10.1038/s41589-026-02181-6.