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首页-抗体药物偶连体和PROTACs-E3 Ligase Ligand-EN106
EN106

Chemical Structure : EN106

CAS No.: 757192-67-9

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EN106 (EN-106)

货号: PC-38760Not For Human Use, Lab Use Only.

EN106 is a cysteine-reactive covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation, PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively.

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10 mg ￥880 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EN106 is a cysteine-reactive covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation, PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively.

物理化学性质&存储条件

分子量 280.708
分子式 C13H13ClN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide

参考文献

1. Nathaniel J. Henning, et al. J. Am. Chem. Soc. 2022, 144, 2, 701–708.

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