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首页-小分子抑制剂&激动剂-Others-Other Targets-EN020
EN020

Chemical Structure : EN020

CAS No.: 1356660-74-6

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EN020 (EN-020)

货号: PC-25437Not For Human Use, Lab Use Only.

EN020 is a novel small molecule modulator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 14.2 µM (MST) and 35.9 µM (SPR), significantly enhances microglial phagocytosis in BV2 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EN020 is a novel small molecule modulator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 14.2 µM (MST) and 35.9 µM (SPR), significantly enhances microglial phagocytosis in BV2 cells.

物理化学性质&存储条件

分子量 318.72
分子式 C14H11ClN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-chloropyridin-3-yl 2-(5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate

参考文献

1. Sungwoo Cho, et al. bioRxiv [Preprint]. 2025 Aug 28:2025.08.23.671917.

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