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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-ELQ-271
ELQ-271

Chemical Structure : ELQ-271

CAS No.: 1023961-72-9

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ELQ-271

货号: PC-24761Not For Human Use, Lab Use Only.

ELQ-271 is a potent, orally bioavailable inhibitor of T. gondii growth in vitro (IC50=0.1 nM) and is effective against acute and latent toxoplasmosis in mice, inhibits cytochrome c reduction by the T. gondii cytochrome bc(1) complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ELQ-271 is a potent, orally bioavailable inhibitor of T. gondii growth in vitro (IC50=0.1 nM) and is effective against acute and latent toxoplasmosis in mice, inhibits cytochrome c reduction by the T. gondii cytochrome bc(1) complex.
ELQ-271 has ED(50) value of 0.14 mg/kg when administered orally to mice with acute toxoplasmosis.
ELQ-271 is highly active against the cyst form of T. gondii in mice at low doses, reducing cyst burden by 76-88% after 16 d of treatment.

物理化学性质&存储条件

分子量 361.32
分子式 C19H14F3NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)pyridin-4(1H)-one

参考文献

1. Doggett JS, et al. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41.

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