EJC-i (Exon Junction Complex inhibitor) | EJC inhibitor, eIF4A3 inhibitor

Chemical Structure : EJC-i

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EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor)

货号: PC-25745Not For Human Use, Lab Use Only.

EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor) is a selective ATP-competitive eIF4A3 ATPase inhibitor with IC50 of 0.97 uM and SPR KD of 0.2 uM, has excellent selectivity over other helicases, inhibits de novo Exon Junction Complex (EJC) assembly.

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生物&药学活性

EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor) is a selective ATP-competitive eIF4A3 ATPase inhibitor with IC50 of 0.97 uM and SPR KD of 0.2 uM, has excellent selectivity over other helicases, inhibits de novo Exon Junction Complex (EJC) assembly.
EJC-i (eIF4A3 inhibitor 18) is a valuable chemical probe to elucidate the detailed functions of eIF4A3 and EJC.

物理化学性质&存储条件

分子量	255.67
分子式	C12H11ClFNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Chloro-7-fluoro-6-isopropyl-1H-indole-2-carboxylic acid

参考文献

1. Villa T, et al. Nucleic Acids Res. 2025 Nov 13;53(21):gkaf1200.

2. Ito M, et al. Bioorg Med Chem. 2017 Apr 1;25(7):2200-2209.

EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor)

生物&药学活性

物理化学性质&存储条件

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EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor)

生物&药学活性

物理化学性质&存储条件

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