EIDD-2749 (4'-Fluorouridine) | Antiviral agent | Probechem Biochemicals

Chemical Structure : EIDD-2749

CAS No.: 1613589-24-4

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EIDD-2749 (4'-Fluorouridine, 4'-FlU)

货号: PC-25957Not For Human Use, Lab Use Only.

4'-Fluorouridine (4'-FlU, EIDD-2749) is a a broad-spectrum orally efficacious ribonucleoside analog that inhibits RSV, SARS-CoV-2 and related RNA viruse LASV, targets RSV and SARS-CoV-2 RdRP causes sequence-modulated transcriptional stalling.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

4'-Fluorouridine (4'-FlU, EIDD-2749) is a a broad-spectrum orally efficacious ribonucleoside analog that inhibits RSV, SARS-CoV-2 and related RNA viruse LASV, targets RSV and SARS-CoV-2 RdRP causes sequence-modulated transcriptional stalling.
4'-Fluorouridine (4'-FlU, EIDD-2749) shows potent dose-dependent activity against recombinant RSV A2-line19F (recRSV A2-L19F) and clinical RSV isolates with EC50 of 0.61-1.2 uM.
4'-Fluorouridine (4'-FlU, EIDD-2749) inhibits RSV and paramyxovirus RdRP complex activity in cell-based minireplicon systems.
4'-Fluorouridine (4'-FlU, EIDD-2749) is efficiently anabolized in HAE cells and is efficacious in human airway epithelium organoids.
4'-Fluorouridine (4'-FlU, EIDD-2749) is orally efficacious in a therapeutic dosing regimen in a small-animal model of RSV infection.
4'-Fluorouridine (4'-FlU, EIDD-2749) is effective against SARS-CoV-2 in HAE and the ferret model.
4'-Fluorouridine (4'-FlU, EIDD-2749) also potently inhibits pathogenic arenaviruses Old World Lassa virus (LASV) and New World Junín virus (JUNV), in pig models of lethal disease.

物理化学性质&存储条件

分子量	262.19
分子式	C9H11FN2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

参考文献

1. Schrell L, et al. Antiviral Res. 2025 Jan;233:106046. doi: 10.1016/j.antiviral.2024.106046.

2. Lieber CM, et al. DNA Cell Biol. 2022 Aug;41(8):699-704.

3. Welch SR, et al. Sci Transl Med. 2024 Nov 20;16(774):eado7034.

4. Sourimant J, et al. Science. 2022 Jan 14;375(6577):161-167.

EIDD-2749 (4'-Fluorouridine, 4'-FlU)

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EIDD-2749 (4'-Fluorouridine, 4'-FlU)

生物&药学活性

物理化学性质&存储条件

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