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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-EGT710
EGT710

Chemical Structure : EGT710

CAS No.: 2893895-11-7

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EGT710 (NVP-EGT710, EGT-710)

货号: PC-26050Not For Human Use, Lab Use Only.

EGT710 (NVP-EGT710) is a potent, selective and oral nonpeptidomimetic reversible covalent SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, shows cellular potency with IC50 of 11 nM in CPE assay in Vero E6 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EGT710 (NVP-EGT710) is a potent, selective and oral nonpeptidomimetic reversible covalent SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, shows cellular potency with IC50 of 11 nM in CPE assay in Vero E6 cells.

物理化学性质&存储条件

分子量 383.33
分子式 C19H12F3N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-3-(Isoquinolin-4-yl)-2-oxo-1-(6-(trifluoromethyl)pyridin-3-yl)imidazolidine-4-carbonitrile

参考文献

1. Papillon JPN, et al. J Med Chem. 2026 Feb 9. doi: 10.1021/acs.jmedchem.5c02360.

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