EDO-S101 (Tinostamustine) | HDAC inhibitor, DNA alkylator

Chemical Structure : EDO-S101

CAS No.: 1236199-60-2

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EDO-S101 (NL-101, Tinostamustine)

货号: PC-42421Not For Human Use, Lab Use Only.

EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.
EDO-S101 (Tinostamustine) displays potent activity in vitro in MM cell lines (IC50=1.6-4.8 uM) and ex vivo in cells isolated from MM patients.
EDO-S101 (Tinostamustine) shows activity in CB17-SCID murine plasmacytoma model and in de novo Vk*MYC mice, also is the only drug with single-agent activity in the multidrug resistant Vk12653 murine model.

物理化学性质&存储条件

分子量	415.36
分子式	C19H28Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-

参考文献

1. Mehrling T, et al. Anticancer Agents Med Chem. 2016;16(1):20-8.

2. López-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20;10(1):127.

3. Besse L, et al. Blood Cancer J. 2017 Jul 28;7(7):e589.

EDO-S101 (NL-101, Tinostamustine)

生物&药学活性

物理化学性质&存储条件

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EDO-S101 (NL-101, Tinostamustine)

生物&药学活性

物理化学性质&存储条件

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