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首页-小分子抑制剂&激动剂-Autophagy-LRRK2-EB-42168
EB-42168

Chemical Structure : EB-42168

CAS No.: 2390475-78-0

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EB-42168 (EB42168)

货号: PC-21888Not For Human Use, Lab Use Only.

EB-42168 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 1.1 nM (pS935-LRRK2) in FRET-based assay, >100-fold selective over WT-LRRR2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    EB-42168 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 1.1 nM (pS935-LRRK2) in FRET-based assay, >100-fold selective over WT-LRRR2.

    物理化学性质&存储条件

    分子量 500.57
    分子式 C25H28N10O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4,5,7,7-Tetramethyl-N-(3-(2-morpholinopyridin-4-yl)-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide

    参考文献

    1. Albert W Garofalo, et al. J Med Chem. 2020 Dec 10;63(23):14821-14839.

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