E6795 | PAR-2 inhibitor | Probechem Biochemicals

Chemical Structure : E6795

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E6795 (E-6795)

货号: PC-25413Not For Human Use, Lab Use Only.

E6795 (E-6795) is a potent, selective and orally available protease-activated receptor 2 (PAR-2) inhibitor with IC50 of 6.56 nM in cell-based calcium influx assays.

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生物&药学活性

E6795 (E-6795) is a potent, selective and orally available protease-activated receptor 2 (PAR-2) inhibitor with IC50 of 6.56 nM in cell-based calcium influx assays.
E6795 does not inhibit thrombin-induced PAR-1 activity, also exhibits high selectivity for PAR-2 over broad kinase and pharmacological panels.
E6795 suppresses inflammation and immune cell infiltration in the MC903-induced AD mouse model
E6795 not only attenuates dermatitis and reduces dermal inflammatory cell infiltration but also improves epidermal barrier function directly or indirectly in the MC903 mouse model.
Topical 2 % E6795 cream reduces inflammation, epidermal thickening, and pruritus in Nc/Nga mice.

物理化学性质&存储条件

分子量	602.01
分子式	C29H27ClF3N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3R,4S)-1-(5-(4-chloro-3,5-difluorophenyl)-7-((2-fluoro-6-methylphenyl)(methyl)amino)pyrazolo[1,5-a]pyrimidine-2-carbonyl)-3-methoxypiperidin-4-yl)acetic acid

参考文献

1. Kitayama N, et al. Biochem Biophys Res Commun. 2025 Sep 3;782:152590.

E6795 (E-6795)

生物&药学活性

物理化学性质&存储条件

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E6795 (E-6795)

生物&药学活性

物理化学性质&存储条件

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