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首页-抗体和重组蛋白-Biosimilar Antibody-Dupilumab
Dupilumab

Chemical Structure : Dupilumab

CAS No.: 1190264-60-8

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Dupilumab (Anti-human IL-4,IL-13 mAb, human IgG1-Kappa; REGN-668; SAR-231893)

货号: PC-Ab1085Not For Human Use, Lab Use Only.

Dupilumab (REGN-668, SAR-231893) is a human monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab down-regulates TH2 inflammation in a variety of allergic disorders, including atopic dermatitis, asthma and possibly other allergic diseases. Besides, Dupilumab was shown to inhibit IgE production by ex-vivo B cells induced by IL-4 treatment..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dupilumab (REGN-668, SAR-231893) is a human monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab down-regulates TH2 inflammation in a variety of allergic disorders, including atopic dermatitis, asthma and possibly other allergic diseases. Besides, Dupilumab was shown to inhibit IgE production by ex-vivo B cells induced by IL-4 treatment.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Dupilumab; Dupixent; REGN-668;SAR-231893; 1190264-60-8; Anti-human IL-4; anti-human Interleukin 13; IL-4 and IL-13 signaling antagonist; Anti-human IL4 Receptor

参考文献

1. 1, Wenzel S, et al. N Engl J Med. 2013 Jun 27;368(26):2455-66. 2, Wechsler ME. N Engl J Med. 2013 Jun 27;368(26):2511-3. 3, Castro M, et al. N Engl J Med. 2018 Jun 28;378(26):2486-2496. 4, Harb H, et al. Clin Exp Allergy. 2020 Jan;50(1):5-14.

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