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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-Duloxetine
Duloxetine

Chemical Structure : Duloxetine

CAS No.: 116539-59-4

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Duloxetine ((S)-Duloxetine, LY248686, LY-248686)

货号: PC-26223Not For Human Use, Lab Use Only.

Duloxetine (LY248686) is a potent serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, also inhibitsvoltage-dependent K+ channels (Kv channels) with IC50 of 4.95 uM for arterial Kv currents.

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100 mg ￥1280 In stock
250 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Duloxetine (LY248686) is a potent serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, also inhibitsvoltage-dependent K+ channels (Kv channels) with IC50 of 4.95 uM for arterial Kv currents.

物理化学性质&存储条件

分子量 297.42
分子式 C18H19NOS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine

参考文献

1. De Berardis, D. et al. Int J Immunopathol Pharmacol, 2010. 23(2): p. 417-22.

2. Jeong J, et al. Eur J Pharmacol. 2025 Oct 15;1005:178110.

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