Dual GO/LDHA inhibitor 2 | GO/LDHA inhibitor | Probechem Biochemicals

Chemical Structure : Dual GO/LDHA inhibitor 2

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Dual GO/LDHA inhibitor 2 (OPPFSA 2)

货号: PC-25944Not For Human Use, Lab Use Only.

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生物&药学活性

Dual GO/LDHA inhibitor 2 is a first-in-class, orally bioavailable dual inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) with Ki of 390 nM and 40 nM, also promotes hydrophobic tag-mediated autophagic degradation of LDHA.
Dual GO/LDHA inhibitor 2 (20 mg/kg/day) degrades hepatic LDHA, decreases urinary oxalate, and diminishes renal deposition of calcium-oxalate crystals in the liver of PH1 mice.
Dual GO/LDHA inhibitor 2 (20 mg/kg body weight) exhibits a significant reduction in urinary oxalate levels and urinary glycolate levels at the renal level of PH1 mice.

物理化学性质&存储条件

分子量	577.72
分子式	C37H39NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-{5-{(E)-3-{4-[6-(Adamantan-1-ylmethylamino)hex-1-ynyl]phenyl}-3-oxoprop-1-enyl}furan-2-yl}-2-hydroxybenzoic Acid

参考文献

1. Arias F, et al. J Med Chem. 2026 Jan 2. doi: 10.1021/acs.jmedchem.5c02055.

Dual GO/LDHA inhibitor 2 (OPPFSA 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dual GO/LDHA inhibitor 2 (OPPFSA 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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