Drpitor1a

Chemical Structure : Drpitor1a

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货号: PC-26858Not For Human Use, Lab Use Only.

Drpitor1a is a selective, potent dynamin-related protein 1 (Drp1) inhibitor with IC50 of 0.06 uM for mitochondrial fragmentation, inhibits the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1.

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生物&药学活性

Drpitor1a is a selective, potent dynamin-related protein 1 (Drp1) inhibitor with IC50 of 0.06 uM for mitochondrial fragmentation, inhibits the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1.
Drpitor1a reduces proliferation and induced apoptosis in cancer cells.
Drpitor1a suppresses lung cancer tumor growth in a mouse xenograft model.
Drpitor1a also inhibitsmitochondrial ROS production, prevented mitochondrial fission, and improves right ventricular diastolic dysfunction during IR injury.

物理化学性质&存储条件

分子量	248.24
分子式	C15H8N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione

参考文献

1. Danchen Wu, et al. FASEB J. 2020 Jan;34(1):1447-1464.

Drpitor1a

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Drpitor1a

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