Dracorhodin perchlorate

Chemical Structure : Dracorhodin perchlorate

CAS No.: 125536-25-6

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货号: PC-25362Not For Human Use, Lab Use Only.

Dracorhodin perchlorate is a potent CD147 inhibitor that induces autophagy-dependent degradation, triggers PUFA/MUFA balance-mediated ferroptosis.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

Dracorhodin perchlorate is a potent CD147 inhibitor that induces autophagy-dependent degradation, triggers PUFA/MUFA balance-mediated ferroptosis.
Dracorhodin perchlorate significantly inhibits cell proliferation and enhances sensitivity to gemcitabine in pancreatic cancer cells.
CD147 inhibition upregulates acyl-CoA synthetase long-chain family member 4 (ACSL4) expression through H3K9 lactylation and suppresses the sterol regulatory element-binding protein 1 (SREBP1)/stearoyl-CoA desaturase-1 (SCD1) signaling pathway, collectively disrupting the balance of polyunsaturated and monounsaturated fatty acids, ultimately triggering ferroptosis.
The combination of Dracorhodin and gemcitabine demonstrates remarkable synergistic anti-tumor effects in orthotopic xenograft models, spontaneous KPC mouse models, and patient-derived organoid (PDO) and xenograft (PDX) models.

物理化学性质&存储条件

分子量	366.75
分子式	C17H15ClO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Hydroxy-5-methoxy-6-methyl-2-phenylchromenylium perchlorate

参考文献

1. Li J, et al. Cell Rep Med. 2025 Aug 19;6(8):102292.