DrOTOP1 inhibitor C2.2

Chemical Structure : DrOTOP1 inhibitor C2.2

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货号: PC-25636Not For Human Use, Lab Use Only.

DrOTOP1 inhibitor C2.2 is a potent, specific small molecule inhibitor of zebrafish (Danio rerio) Otopetrin 1 (DrOTOP1) proton-selective ion channel with IC50 of 6.67 uM in HEK-293 cells expressing DrOTOP1 (pH 5.5).

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50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

DrOTOP1 inhibitor C2.2 is a potent, specific small molecule inhibitor of zebrafish (Danio rerio) Otopetrin 1 (DrOTOP1) proton-selective ion channel with IC50 of 6.67 uM in HEK-293 cells expressing DrOTOP1 (pH 5.5).
C2.2 is slightly less effective at inhibiting DrOTOP1 currents at pH 5.0, while no difference was observed between pH 6.0 and pH 5.5 (IC50 values were: pH 6.0: 5.97 µM, pH 5.5: 6.67 µM, and pH 5.0: 12.6 µM).
C2.2 fully blocked currents at 200 µM in whole-cell patch-clamp recording of DrOTOP1 expressed in HEK-293 cells.
C2.2 significantly inhibited mouse OTOP1 (mOTOP1), but not human (Homo sapiens) OTOP1 (hOTOP1).
C2.2 is specific for DrOTOP1 over mammalian orthologs.
Otopetrins (OTOPs) are a conserved, eukaryotic family of proton-selective ion channels, OTOP1 serves as a gustatory sensor for sour tastes and ammonium chloride.

物理化学性质&存储条件

分子量	271.32
分子式	C15H17N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methyl-N-(2-((2-methylallyl)oxy)phenyl)-1H-imidazole-4-carboxamide

参考文献

1. Burendei B, et al. Nat Commun. 2025 Oct 23;16(1):9362.