DnaK inhibitor M7

Chemical Structure : DnaK inhibitor M7

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货号: PC-28084Not For Human Use, Lab Use Only.

DnaK inhibitor M7 is a small molecule inhibitor of bacterial Hsp70 protein DnaK ATPase, inhibits DnaK-mediated ATP hydrolysis with IC50 of 8.4 uM, likely engages the substrate-binding pocket of DnaK, induces accumulation of σ-32 without affecting protein translation, effectively inhibits the growth of E. coli AS19 and some Gram-positive bacteria, including Staphylococcus aureus and Bacillus cereus.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DnaK inhibitor M7 is a small molecule inhibitor of bacterial Hsp70 protein DnaK ATPase, inhibits DnaK-mediated ATP hydrolysis with IC50 of 8.4 uM, likely engages the substrate-binding pocket of DnaK, induces accumulation of σ-32 without affecting protein translation, effectively inhibits the growth of E. coli AS19 and some Gram-positive bacteria, including Staphylococcus aureus and Bacillus cereus.

物理化学性质&存储条件

分子量	919.05
分子式	C46H62N8O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5'-((5,5'-(((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(azanediyl))bis(6-isobutoxypicolinoyl))bis(azanediyl))bis(6-(sec-butoxy)picolinic acid)

参考文献

1. Upadhyay T, et al. Chembiochem. 2026 Sep 14;27(17):e70518.