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首页-抗体药物偶连体和PROTACs-PROTAC-DnAurA-A10
DnAurA-A10

Chemical Structure : DnAurA-A10

CAS No.:

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DnAurA-A10

货号: PC-27878Not For Human Use, Lab Use Only.

DnAurA-A10 is a selective, nuclear-targeted PROTAC degrader of Aurora kinase A (AURKA), induces nuclear AURKA degradation at 10-50 uM in HCT116 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DnAurA-A10 is a selective, nuclear-targeted PROTAC degrader of Aurora kinase A (AURKA), induces nuclear AURKA degradation at 10-50 uM in HCT116 cells.

物理化学性质&存储条件

分子量 1228.95
分子式 C70H83ClFN11O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(10-(4-((2,5-bis(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)phenyl)amino)benzamido)decyl)-4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-2-methoxybenzamide

参考文献

1. Bowen Qian, et al. Biochem Biophys Res Commun. 2026 Aug 18:834:154458.

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