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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldehyde Dehydrogenase (ALDH)-Disulfiram
Disulfiram

Chemical Structure : Disulfiram

CAS No.: 97-77-8

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Disulfiram (Tetraethylthiuram disulfide, TETD)

货号: PC-22705Not For Human Use, Lab Use Only.

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1) with IC50 of 0.13 uM for ALDH1A1 and 3.4 uM for ALDH2, also inhibits USP2 and USP21 with IC50 of 25.0 and 3.7 uM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1) with IC50 of 0.13 uM for ALDH1A1 and 3.4 uM for ALDH2, also inhibits USP2 and USP21 with IC50 of 25.0 and 3.7 uM respectively.
Disulfiram also inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.

物理化学性质&存储条件

分子量 296.52
分子式 C10H20N2S4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Bis(diethylthiocarbamoyl) disulfide

参考文献

1. Lipsky J.J., et al. Chem. Biol. Interact. 2001;130–132:93–102.
2. Lin HC, et al. Int J Biol Macromol. 2021 Apr 15;176:490-497.

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