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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Microsomal Triglyceride Transfer Protein (MTP)-Dirlotapide
Dirlotapide

Chemical Structure : Dirlotapide

CAS No.: 481658-94-0

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Dirlotapide (CP742033)

货号: PC-24765Not For Human Use, Lab Use Only.

Dirlotapide (CP742033) is a potent inhibito rof microsomal triglyceride transfer protein (MTP), inhibits Apo B secretion from human HepG2 cells and in canine hepatocytes with IC50 of 1.5 nM and 2.9 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dirlotapide (CP742033) is a potent inhibito rof microsomal triglyceride transfer protein (MTP), inhibits Apo B secretion from human HepG2 cells and in canine hepatocytes with IC50 of 1.5 nM and 2.9 nM respectively.
Dirlotapide showed excellent efficacy when tested in a canine food intake model.

物理化学性质&存储条件

分子量 674.72
分子式 C40H33F3N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-[2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[4'-(trifluoromethyl)-2-biphenylylcarboxamido]indole-2-carboxamide

参考文献

1. Li J, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9.

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