Dioctatin

Chemical Structure : Dioctatin

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货号: PC-25330Not For Human Use, Lab Use Only.

Dioctatin is a small molecule inhibitor of aflatoxin production of Aspergillus flavus, binds to and activates mitochondrial protease ClpP of A. flavus and Escherichia coli.

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生物&药学活性

Dioctatin is a small molecule inhibitor of aflatoxin production of Aspergillus flavus, binds to and activates mitochondrial protease ClpP of A. flavus and Escherichia coli.
Dioctatin inhibits aflatoxin B1 production of A. flavus IFM 47798 strain with IC50 of 23.9 uM.
Dioctatin-bound ClpP selectively degrades mitochondrial energy-related proteins.
Dioctatin reduces TCA cycle metabolites and raises glycolysis and ethanol production.
Dioctatin reduces acetylated histone and expression of aflatoxin biosynthetic genes.

物理化学性质&存储条件

分子量	357.50
分子式	C18H35N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	((S)-3-((S)-3-aminooctanamido)octanoyl)glycine

参考文献

1. Furukawa T, et al. Cell Chem Biol. 2020 Nov 19;27(11):1396-1409.e10.

Dioctatin

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Dioctatin

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