Diltiazem | L-VDCC inhibitor | Probechem Biochemicals

Chemical Structure : Diltiazem

CAS No.: 42399-41-7

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Diltiazem (CRD-401)

货号: PC-25782Not For Human Use, Lab Use Only.

Diltiazem (CRD-401) is a postsynaptic muscle relaxant that inhibits Ca2+ ions release from sarcoplasmic reticulum stores, inhibits L-type voltage-dependent Ca2+ channels (L-VDCC).

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500 mg	￥880	In stock
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生物&药学活性

Diltiazem hydrochloride (CRD-401) is a postsynaptic muscle relaxant that inhibits Ca2+ ions release from sarcoplasmic reticulum stores, inhibits L-type voltage-dependent Ca2+ channels (L-VDCC).
Diltiazem hydrochloride (CRD-401) antagonizes ryanodine receptors (RyR).
Diltiazem hydrochloride (CRD-401) can prevent cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.

物理化学性质&存储条件

分子量	414.52
分子式	C22H26N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-5-(2-(Dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate

参考文献

1. Lu S, et al. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5292-301.

2. Zucchi R, et al. Pharmacol Rev. 1997 Mar;49(1):1-51.

3. Krause T, et al. Anaesthesia. 2004 Apr;59(4):364-73.

Diltiazem (CRD-401)

生物&药学活性

物理化学性质&存储条件

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Diltiazem (CRD-401)

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