Dihexa | c-Met activator | Probechem Biochemicals

Chemical Structure : Dihexa

CAS No.: 1401708-83-5

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Dihexa (PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2)

货号: PC-23261Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Dihexa (PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2) is an oligopeptide drug, orally active and blood-brain barrier-permeable angiotensin IV analog, binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor c-Met.
Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models.
Dihexa exhibits excellent antidementia activity in the scopolamine and aged rat models and marked synaptogenic activity.

物理化学性质&存储条件

分子量	504.67
分子式	C27H44N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-1-(((2S,3S)-1-((6-Amino-6-oxohexyl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)hexanamide

参考文献

1. Benoist CC, et al. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402.

2. McCoy AT, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):141-54.

Dihexa (PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dihexa (PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2)

生物&药学活性

物理化学性质&存储条件

参考文献

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