Deucravacitinib (BMS-986165) | TYK2 inhibitor | Probechem Biochemicals

Chemical Structure : Deucravacitinib

CAS No.: 1609392-27-9

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Deucravacitinib (BMS-986165, BMS 986165)

货号: PC-73037Not For Human Use, Lab Use Only.

BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.
BMS-986165 binds to the TYK2 pseudokinase (JH2) domain, displays unprecedented JAK isoform and kinome selectivity.
BMS-986165 shows excellent pharmacokinetic properties with minimal profiling liabilities and is efficacious in several murine models of autoimmune disease.

物理化学性质&存储条件

分子量	425.47
分子式	C20H19D3N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide

参考文献

1. Wrobleski ST, et al. J Med Chem. 2019 Oct 24;62(20):8973-8995.

Deucravacitinib (BMS-986165, BMS 986165)

生物&药学活性

物理化学性质&存储条件

参考文献

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Deucravacitinib (BMS-986165, BMS 986165)

生物&药学活性

物理化学性质&存储条件

参考文献

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