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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-Deltasonamide 2
Deltasonamide 2

Chemical Structure : Deltasonamide 2

CAS No.: 2088485-34-9

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Deltasonamide 2 (Deltasonamide2)

货号: PC-61154Not For Human Use, Lab Use Only.

Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM.

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10 mg ￥3780 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM.
Deltasonamide 2 inhibits PDE6δ/KRas interaction in cells with Kd of 64 nM, selectively inhibits growth of KRas mutated and -dependent cells.
Deltasonamide 2 inhibits the oncogenic KRas-dependent MiaPaCa-2 with IC50 of 750 nM.

物理化学性质&存储条件

分子量 647.25
分子式 C30H39ClN6O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-((1r,4r)-4-aminocyclohexyl)-N4-(4-chlorobenzyl)-N4-cyclopentyl-N1-((2-(methylamino)pyrimidin-4-yl)methyl)benzene-1,4-disulfonamide

参考文献

1. Martín-Gago P, et al. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.

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