Deguelin

Chemical Structure : Deguelin

CAS No.: 522-17-8

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货号: PC-24602Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg		Get quote

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生物&药学活性

Deguelin is a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis, also is a potential inhibitor of FBXO22.
Deguelin enhanced radiosensitivity in an FBXO22/Rad51-dependent manner and was safely tolerated in vivo.
Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
Deguelin exerts antitumor and chemopreventive effects by targeting multiple oncogenic signaling pathways.

物理化学性质&存储条件

分子量	394.42
分子式	C23H22O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one

参考文献

1. Mehta R, et al. PLoS One. 2013 Jun 10;8(6):e65113.

2. Yang YL, et al. PLoS One. 2013;8(1):e54736.

3. Yunshang Chen, et al. Cell Death Dis. 2024 Jan 31;15(1):104.

Deguelin

生物&药学活性

物理化学性质&存储条件

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Deguelin

生物&药学活性

物理化学性质&存储条件

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